Peripheral Vascular Disease - 元心科技| power by:厦门宏晶

Peripheral Vascular Disease

Peripheral vascular disease (PVD) is a chronic limb ischemic disease. Clinically, vascular diseases other than cardiovascular diseases are collectively referred to as Peripheral vascular diseases, such as atherosclerotic plaques and arterial stenosis occlusion caused by thrombosis (arteriosclerotic occlusion, arterial embolization).

Peripheral Vascular Disease

The most common symptom of peripheral vascular disease is pain, intermittent claudication, which occurs in and out of one or both legs, thighs, or buttocks.The pain often occurs while walking or climbing stairs and stops at rest.Often dull, spasmodic pain.It can also feel like a heavy, tense or tired feeling in the leg muscles.When the blood vessels in the legs are severely blocked, the typical symptom is leg pain at night. Severe resting pain, ulceration, ischemia and necrosis, threatening the entire or part of the lower limb, may occur in the middle or late stages of the disease

Percutaneous balloon angioplasty: a minimally invasive interventional technique is used to dilate an occlusive or stenotic artery without applying open surgery. The catheter with the balloon was introduced by means of intervention, and the balloon was pressurized to expand to exert a certain pressure on the lesion site of artery occlusion, to compress and tighten the atherosclerotic plaque, and then the balloon was deflated and withdrawn slowly, so as to expand the artery lumen, restore arterial patency and restore blood flow.

Stent is a technique used for arteries that begin to close again after angioplasty or severe occlusion.Most peripheral vascular lesions can be treated with stent placement. A stent is a small metal or polymer mesh tube that is fixed in a narrow artery. The stent keeps the artery lumen open, and eventually new tissue will grow to cover the stent. Most patients are treated with metal drug-eluting stents.Common stents on the market are made of non-degradable metal, which is hard to break down and then becomes a permanent implant.

IBS Titan™ Sirolimus-Eluting Iron Bioresorbable Peripheral Scaffold has the following features:

1) Using iron-based materials with good biocompatibility to improve the radial support strength while significantly reducing the thickness of the scaffold rod;

2) Asymmetric coating technology simultaneously solves corrosion and drug release

3) The surface composite coating realizes the controlled degradation of the iron-based scaffold: the new composite coating design is used to slow down the early iron corrosion to ensure the effective support of the scaffold in the early stage and accelerate the iron corrosion rate in the later period.

After the scaffold is implanted, it eliminates the retraction of the blood vessels and gradually releases the medicine, which makes the blood vessels unobstructed and effectively relieves the patients' symptoms. The scaffold loses most of its mechanical support and adapts to tissue regeneration within 3-6 months, and is gradually absorbed by the body to restore exercise capacity. The length of the scaffold reaches 118mm, adapting to the real needs of patients.

1.IBS Sirolimus-Eluting Iron Bioresorbable Coronary Scaffold System has the following innovations:

1) Using iron-based materials with good biocompatibility to improve the radial support strength while significantly reducing the thickness of the scaffold;

2) Asymmetric coating technology simultaneously solves corrosion and drug release

3) The surface composite coating realizes the controllable degradation of the iron-based scaffold: the new composite coating design is used to slow down the early iron corrosion to ensure the effective support of the scaffold in the early stage and accelerate the iron corrosion rate in the later stage.

4)After placing the IBS scaffold in the coronary artery, the drug on the surface of the scaffold was gradually released to inhibit endothelial hyperplasia. At the same time, the polylactic acid coating creates a slightly acidic environment after degradation, which accelerates the corrosion of iron and solves the problem of slow corrosion and absorption rate of iron. Over time, the IBS scaffold is completely degraded, and the trace elements released by the degradation products are absorbed from the body without leaving a permanent implant.

Patients usually relieve symptoms immediately after PCI, and the coronary arteries take 3 to 6 months to recover. Once the coronary arteries heal, the support of the scaffold is no longer required. The iron-based absorbable scaffold is designed to disappear (or "absorb") from the body over time. This absorption helps restore the coronary artery to natural movement and function.

2. Compared with the mainstream permanent metal stents

A) the short-term and long-term risks associated with the permanent retention of the implant in the body are avoided, such as long-term inflammation, displacement and restenosis caused by the long-term stimulation of foreign bodies;

B) long-term dual antibody is not required to reduce the financial burden of patients and the risk of bleeding disease;

C) avoiding the risk of stimulation or even perforation of vessels caused by long-term fatigue fracture (29% of permanent stent fracture rate at autopsy);

D) to avoid long-term inflammation, displacement and restenosis caused by long-term stimulation of foreign bodies;

E) medical examination, the degradation of IBS scaffold does not affect imaging examination such as MRI and CT;

F) the degradation of IBS scaffold will no longer bind the artery.

3.Compared to absorbable polymer scaffolds

A) the safety and efficacy were inferior to that of the early stage of the permanent stent, and the incidence of thrombosis in the middle stage was higher than that of the permanent stent;Limited plasticity;Acute retraction;Poor overexpansion performance; higher strut thickness.

B) few specifications: due to the limitation of the properties of the intrinsic materials of polylactic acid, on the premise of ensuring the mechanical properties, the stent is relatively thick with few specifications, which can only cover 8% or even lower patients with simple lesions in the permanent stent group.

C) strict operational requirements: due to the limitation of the properties of polylactic acid intrinsic materials and the poor mechanical properties of scaffolds, polylactic acid scaffolds can only be applied to simple lesions, while for highly calcified blood vessels, it is necessary to remove calcified plaques in advance to put scaffolds;Adequate balloon predilation was performed on the diseased vessels before scaffold implantation, and the scaffold should be slowly expanded, otherwise the scaffold will break.

D) polylactic acid stent double resistance for a long time, not only increase the cost, but also bring bleeding complications.

E) high storage and transportation requirements

Drug treatment

antithrombotic drugs are prescribed after surgery to help keep blood vessels in the lower extremities open and reduce the formation of scaffold clots. Patients should follow the doctor's instructions to use these drugs.

Change your lifestyle

After the operation, the patient can understand the cause of vascular disease with a doctor or an expert, and should take corresponding treatment measures consciously for the cause, such as quitting smoking and drinking

Patients should maintain proper activity and exercise, keep a healthy diet, eat heart-healthy foods including fruits and vegetables, lean meats and whole grains, and avoid foods high in cholesterol. Maintain a healthy weight, control high blood pressure and high cholesterol, and people with diabetes should control their blood sugar. Patients should pay attention to keep the lower limbs in a state of extension to reduce excessive limb flexion.

Regular medical examination

Regular physical examination at the hospital is helpful for

doctors to track the progress of the patient's condition, so

as to find the restenosis of lower limbs as soon as possible. If you feel that the walking distance of lower limbs is shortened and the symptoms are aggravated, you should go to the hospital in time. Doctors can keep abreast of any changes in symptoms and how patients respond to medication and lifestyle changes to help patients better improve their health by adjusting medications or recommending regimens.

1. Patient age

2. Whether the patient has other health conditions

3. Location and severity of arterial obstruction in the patient

4. Patients with antiplatelet and/or anticoagulant contraindications

5. Patients who cannot receive adequate balloon dilation of angioplasty or scaffold placement at the lesion

6.Patients with iron metabolism disorder or iron overload

7. Persons who are allergic to sirolimus and its derivatives

8. Allergic to polylactic acid and its degradation products

9. Allergic to zinc, iron and their corrosion products

10. Allergic to contrast media

Biotyx Medical (Shenzhen) Co., Ltd.

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http://www.lifetechmed.com/

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